What Weight Loss Pills Actually Work Review

There are numerous weight loss methods available.

Including pills, medicines, and natural supplements.

These are said to help you lose weight, or at least make other techniques simpler.

This is how they usually work:

1. Make you feel fuller, so you eat less.

2. Reduce nutrient absorption, reducing calorie intake

3. Increase fat burning and calorie burn

The science behind the 12 most popular weight loss medications and supplements.

1. Garcinia Cambogia Extract

Garcinia cambogia gained widespread popularity after appearing on Dr Oz in 2012.

It’s a green pumpkin-shaped fruit.Carcinia-Bomogia-Extract

Fruit skin contains hydroxycitric acid (HCA).

This is the active ingredient in the diet pill Garcinia Cambogia extract.

It works:

It reduces cravings by raising serotonin levels and blocking a fat-producing enzyme in animals.

Research with 130 patients compared garcinia to a placebo.

The groups had the same weight and body fat percentage.

A 2011 meta-analysis of 12 research revealed it reduced weight by 2 pounds (0.88 kg) over weeks.

No major negative effects have been reported, but moderate digestive issues have been.

Garcinia cambogia may cause moderate weight loss, but the results are likely imperceptible.


Hydroxycut has been around for almost a decade and is still going strong.

There are various sorts, but the most prevalent is “Hydroxycut.”HudroxyCut-Lose-Weight-Talblets

It works: Caffeine and plant extracts are among the components that are said to aid in weight loss.

Effectiveness: One study found it helped people lose 21 lbs (9.5 kg) in 3 months.

Caffeine sensitivity causes anxiety, jitteriness, tremors, nausea, diarrhea, and irritability.


This supplement has only one research and no data on long-term effectiveness.

The search continues.

3. Caffeine:

Caffeine is the world’s most popular psychoactive.

Coffee, green tea, and dark chocolate naturally contain it.

Calorie-boosting caffeine is commonly used in commercial weight-loss products.

It works: Caffeine has been shown to increase metabolism and fat burning by 3-11 per cent.

Caffeine has been shown in several trials to produce modest weight loss in adults.

Caffeine can produce

  • anxiety
  • insomnia
  • jitteriness
  • irritability
  • nausea
  • diarrhea and other symptoms.

Caffeine is also addicting and can disrupt sleep.

There is no need to use a caffeine supplement or pill.

Optimal sources are high-quality coffee and green tea, both of which contain antioxidants.

Caffeine can temporarily increase metabolism and fat burning.

Toxicity tolerance can develop quickly.

4. Xenical (Alli)

Orlistat is a prescription medication sold under the brand names Xenical and Alli.

This weight loss tablet works by preventing the breakdown of fat in the intestines, reducing fat intake.Alli-Weight-Loss-Aid

Based on 11 research, orlistat increased weight loss by 6 lbs (2.7 kg) over placebo.

Other gains: In one trial, orlistat lowered the risk of type 2 diabetes by 37%.

Side effects include loose, greasy stools, gas, and frequent, difficult-to-control bowel motions.

A, D, E, and K deficiencies may result.

A low-fat diet is usually recommended to avoid orlistat side effects.

Orlistat (without medicines) is as successful as a low-carb diet plus orlistat (without drugs).

Short answer:

Orlistat (Alli or Xenical) can help you lose weight by decreasing the fat you absorb from food.

It has several adverse side effects.

5. Raspberry Ketones

Raspberry ketone is the smelly chemical present in raspberries.

Dietary supplements with raspberry ketones are available.

What it is:

Raspberry ketones boost fat breakdown and adiponectin levels in rat fat cells isolated for research.

High doses of raspberry ketones decreased weight gain in rats, but no human research exist.

Their side effects include a raspberry-like burp fragrance.

The rat trials showing it worked employed massive dosages of raspberry ketones.

6. Green Coffee Extract

Green coffee beans are just unroasted coffee beans.

Caffeine and chlorogenic acid are two ingredients thought to aid in weight loss.

In the intestines, chlorogenic acid and caffeine work together to enhance fat burning.

Green coffee bean extract has been found in several human tests to aid in weight loss.Raw-Coffee-Beans

From a meta-analysis of three studies, the supplement caused participants to lose 5.4 pounds (2.5 kg).

The extract may also help control blood sugar and blood pressure.

It is also an antioxidant.

Caffeine-like side effects are possible.

There is a risk of diarrhoea from the chlorogenic acid in it, and some people are allergic.


However, many studies on green coffee bean extract were supported by industry.

7. Glucomannan

In the elephant yam, commonly known as konjac root, is glucomannan, a fibre.

It absorbs water and gels. As it “sits” in your gut, it helps you feel fuller for longer.

According to three human studies, it can help patients shed 8-10 pounds (3.6-4.5 kg) in 5 weeks.

Intestinal friendly bacteria feed on glucomannan, which is also fibre.

It also helps with constipation and lowers blood sugar, cholesterol, and triglycerides.

When taken concurrently with some oral drugs, it can induce gas, flatulence, and soft stools.

Take glucomannan 30 minutes before meals with a glass of water to avoid stomach upset.

A good assortment is available on Amazon if you want to try it.


Weight loss has been linked to glucomannan fibre and a nutritious diet.

It also improves specific health indicators.

8. Meratrim

Meratrim is a newer diet drug.

It is a plant extract blend that may alter fat cell metabolism.Meratrim-800-mg-Weight-Loss

It’s supposed to decrease fat cell growth, limit blood fat absorption, and aid in fat burning.


Meratrim has only one research.

100 obese persons were put on a rigorous 2000 calorie diet with Meratrim or a dummy pill for comparison.

By the end of 8 weeks, the Meratrim group had dropped 11 lbs (5.2 kg) and 4.7 inches (11.9 cm).

They had a better quality of life and lower blood sugar, cholesterol, and triglycerides.

No known adverse effects.


Meratrim produced weight loss and had other health benefits, according to one research study.

But the study was funded by industry, and further research is required.

9. Green Tea Extract

In many weight loss supplements, green tea extract is used.

Because its major antioxidant, EGCG, has been shown to promote fat loss in multiple studies.

The mechanism is assumed to be an increase in norepinephrine, a fat-burning hormone.


Green tea extract has been shown to increase fat metabolism and reduce abdominal fat in people.

Green tea extract has no known side effects.

Caffeine sensitive people may get results with this product.

Also, all the health benefits of green tea should apply to green tea extract.


10. Linoleic Acid Conjugated (CLA)

A popular fat-burning supplement for years, CLA is a linoleic acid derivative.

Some fatty animal foods, such as cheese and butter, naturally contain this trans fat.

CLA may suppress hunger, increase metabolism, and promote fat decomposition.

It worked for up to 6 months, according to a meta-analysis of 18 research.

A study published in 2021 indicated that CLA can help you lose 3 lbs (1.3 kg) faster than a placebo.

CLA has been linked to fatty liver, insulin resistance, and elevated inflammation in the short term.


CLA is a good fat burner. However, it has side effects. The slight weight loss isn’t worth the risk.

11. Forskolin

Weight loss claims are made for forskolin, an extract from a mint family plant.

It is thought to function by increasing cAMP levels in cells, which may help with fat loss and weight loss.Forskolin-Fat-Burner

In a study of 30 overweight and obese people, forskolin boosted muscle growth and decreased body fat.

Similar research of 23 obese women revealed no impact.

The supplement’s safety and side effect risks are unknown.


Forskolin has mixed results from two short studies. This supplement should be avoided until more study is done.

12. Synephrine (Bitter Orange)

Synephrine is found in bitter orange.

In fact, synephrine is connected to ephedrine, another prominent chemical in diet pills.

The FDA has since prohibited ephedrine from weight loss products due to serious adverse effects.

What it is:

Synephrine is a less potent version of ephedrine.

It can suppress appetite and increase fat metabolism.

Only a few studies have looked at synephrine’s effectiveness.

However, several have found ephedrine to induce considerable short-term weight loss.

Synephrine, like ephedrine, has substantial cardiovascular adverse effects. It might be addictive.


Synephrine is a potent stimulant that may help you lose weight quickly.

Side effects are severe, therefore use with caution.


There are also numerous proven effective prescription weight loss medicines.

Contrave, Phentermine, and Qsymia are the most common.

A 2014 research found that even prescription weight loss medicines don’t work as advertised.

Compared to a dummy pill, they can help you lose 3-9 per cent more weight.

Combined with a balanced weight loss diet, this works best.

On their own, they are ineffectual and do not address obesity.

Not to mention the negative repercussions.

Final Words

In terms of evidence, these 12 stand out as clear winners:

• Caffeine and green tea extract

• Glucomannan, CLA, and Orlistat

Yet I strongly advise against Orlistat and CLA due to their detrimental metabolic effects.

Glucomannan, green tea extract and caffeine remain.

However, the benefits are minimal.

Sadly, NO weight-loss supplement or tablet works as effectively.

They may boost your metabolism and help you shed a few pounds, but that’s about all.

Eating fewer carbs and more protein is still the best method to reduce weight.

I hope you had a good time reading my blog.

Please post any questions or comments in the section below.

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What Weight Loss Pills Actually Work Review